ʻO Vanessa Chen

Jiangsu Konsung Bio-Medical Science and Technology Co., Ltd. Nanjing 210012, Jiangsu, Kina

Puhi: ʻO ka anemia, kahi maʻi maʻamau i ka honua holoʻokoʻa, ka hopena nui i ke olakino a me ka maikaʻi o ke ola no nā haneli miliona o nā kānaka. He mea koʻikoʻi ka nānā mua ʻana no ka hoʻomaikaʻi ʻana i ka prognosis o nā maʻi a me ka hōʻemi ʻana i ke kaumaha o ka maʻi. Me ka hāʻule ʻana o nā kumu lāʻau lapaʻau i ka pae ʻāina, pono e hoʻomohala i nā hāmeʻa nānā pono a kūpono hoʻi. Lawe kēia ʻatikala i ka Konsung Hemoglobin Analyzer (H7 series) ma ke ʻano he noiʻi a hoʻopaʻa i ka waiwai noi o kāna kumu ʻike spectrophotometric i ka nānā ʻana i ka anemia. Ma o ka hoʻopololei ʻōnaehana o nā ʻāpana hana mea kani, nā ʻikepili hōʻoia hōʻoia o nā kikowaena multicenter, a me ka hoʻohālikelike ʻana me nā ʻano hoʻokolohua maʻamau, ua ʻike ʻia ua hōʻike ka mea hana i ka pololei kiʻekiʻe (± 2% hapa hapa) a me ka hana kiʻekiʻe (3 kekona/sample) i ka hemoglobin quantitative detection. ʻO kāna hoʻolālā lawe lima a me ke kaʻina hana maʻalahi i hoʻohaʻahaʻa loa i ka paepae no nā limahana lapaʻau mua e hoʻohana ai. He kūpono loa ia no ka nānā ʻana i ka nui ma nā keʻena olakino mua. Ua hōʻike pū ʻia ka haʻawina he 92.3% ka nānā mua ʻana o ka hāmeʻa no ka anemia deficiency hao, hiki ke hoʻomaopopo pono i nā pūʻulu koʻikoʻi, hāʻawi i kahi kumu hilinaʻi no ka maʻi maʻi a me ka mālama ʻana, a he waiwai koʻikoʻi koʻikoʻi i ka hoʻoikaika ʻana i ka neʻe mua o ka pale ʻana i ka anemia a me ka mālama ʻana a me ka loaʻa ʻana o ka maʻi mua a me ka mālama ʻana.

Hua'ōlelo: Hemoglobin analyzer; ka nānā ʻana i ka anemia; Spectrophotometry; Konsung H7; ʻO ka pololei o ka diagnostics

Hoʻolauna

ʻO ka Anemia kahi maʻi maʻi maʻi o nā pae hemoglobin (HB) ma lalo o ka maʻamau, me ka nui o ka honua ma kahi o 24.8%, a ʻo ka anemia nele i ka hao he 50%. ʻAʻole alakaʻi wale ʻia ka anemia lōʻihi i ka nawaliwali a me ka hana cognitive impaired, akā hiki ke hoʻoulu i nā maʻi cardiovascular a me ka cerebrovascular, ʻoi aku ka nui o ka

hoʻoweliweli nui i nā hui kūikawā e like me nā wahine hāpai a me nā keiki. Eia nō naʻe, ʻo ka screening kuʻuna, e hilinaʻi nei i nā hoʻāʻo koko maʻamau a koi i nā mea hana automated nui, loaʻa nā pilikia e like me ke kumukūʻai kiʻekiʻe o ka lako, ka hana paʻakikī, a me nā pōʻai hoʻāʻo lōʻihi, e paʻakikī ana e hoʻokō i ka koi no ka maʻi wikiwiki i ka mālama olakino mua [1]. Ua kaulana ka Konsung hemoglobin analyser (H7 series) i ka nānā ʻana i ka anemia ma nā keʻena lapaʻau mua e hoʻomaikaʻi i kona hiki ke lawe a me ka hiʻohiʻona ʻike wikiwiki (manawa ʻike ≤ 3 kekona). Hoʻohana ka hāmeʻa i ka spectrophotometry kiʻekiʻe e wāwahi i ka bottleneck ʻenehana o ka ʻike kuʻuna. Hiki iā ia ke hoʻokō pololei me ka liʻiliʻi o ke koko i hōʻiliʻili ʻia mai ka manamana lima, me ka hoʻomaikaʻi nui ʻana i ka pono o ka screening a me ka hoʻokō hoʻomanawanui. ʻIke ʻia kēia ʻatikala i ka pono o ka ʻike ʻana o ka hāmeʻa a me kāna waiwai noiʻi lapaʻau, me ka manaʻo e hāʻawi i kahi kumu ʻepekema no ka hoʻomaikaʻi ʻana i nā papahana screening anemia a me ka hoʻolaha ʻana i ka lāʻau lapaʻau hierarchical, a e kōkua i ka hoʻoponopono ʻana i ka ʻoiaʻiʻo o ka nele o nā kumu lāʻau lapaʻau ma ka pae mua.

Nā hiʻohiʻona ʻenehana o Konsung hemoglobin analyzer

ʻO ke kumu ʻike a me nā ʻāpana kumu

ʻO ka hāmeʻa, e pili ana i ke kumu o kahi spectrophotometer, e ana i ka neʻe ʻana o ka hemoglobin i loko o nā laʻana koko holoʻokoʻa ma ke ʻano SLS-Hb, me kahi ākea ʻike o 0-250g/L a me kahi hoʻonā o 1g/L [2]. ʻO kāna mau mea nui he microfluidic chip, kahi kumu kukui hawewe 532nm a me nā mea ʻike photoelectric, e helu ana i ka ʻike HB ma ke ana ʻana i ka waiwai absorption māmā o ka hopena ma hope o ka hemolysis. Ua hōʻike ka hōʻoia hōʻoia i ka pilina o 0.98 (P

Nā pono hana a me nā palena

Pono

1. ʻO ka wikiwiki a me ka maʻalahi: ʻAʻohe pono no ka hoʻomaʻamaʻa mua ʻana, ʻo 7μL wale nō o ke koko manamana lima e pono ai e hoʻopau i ka hoʻāʻo, mālama ʻia 90% o ka manawa hōʻiliʻili hāpana i hoʻohālikelike ʻia i nā hoʻokolohua maʻamau koko. He maʻalahi a intuitive ka mea kani, a ma hope o ka hoʻomaʻamaʻa maʻamau, hiki i nā limahana lapaʻau ʻole ke hoʻopau i ka hōʻike hōʻike i hoʻokahi minuke, e hoʻomaikaʻi nui ana i ka pono screening [3]. No ka laʻana, i ka nānā kino ʻana o ka poʻe ʻelemakule ma ke kaiāulu, hiki i ka nui o ka hoʻāʻo ʻana i kēlā me kēia lā ke piʻi i ʻekolu manawa ma mua o nā mea hana maʻamau.
2. ʻO ke kumu kūʻai: ʻO ke kumukūʻai o nā mea hoʻohana no ka hoʻāʻo hoʻokahi he 30% haʻahaʻa ma mua o ka hoʻomaʻamaʻa koko maʻamau, a maʻalahi nā mea hana a ʻaʻole koi i ka calibration pinepine.
3. Nā hiʻohiʻona noiʻi: He paʻa a hiki ke lawe ʻia ka hāmeʻa, kūpono loa no nā hiʻohiʻona me nā kumuwaiwai liʻiliʻi e like me nā kikowaena hoʻokolokolo kino, nā waihona koko, nā kaʻa hāʻawi koko, a me nā halemai kaiaulu [4]. Ma nā kūkākūkā lapaʻau manuahi ma nā wahi mamao a i ʻole ka nānā ʻana i ke olakino no nā limahana ʻoihana, ʻo kāna hiʻohiʻona ʻaʻole e koi i kahi lako mana o waho (me kahi pākaukau kūloko e mau ana ma mua o 8 mau hola) e hoʻoponopono maikaʻi i ka pilikia o nā mea hana kuʻuna e hilinaʻi nei i nā kaiapuni ʻoihana a hoʻolaha i ka hoʻonui ʻana o nā lawelawe screening anemia i nā ʻuʻu a me nā terminal mobile.

Hoʻohui ʻikepili

Hoʻolako ʻia me ka hiki ke hoʻoili Bluetooth, hoʻohui ʻia me nā ʻikepili lapaʻau kūloko no ka kaʻana ʻike ʻike manawa maoli. Hiki i nā mea mālama ola kino ke hoʻouka wikiwiki i nā hopena i nā halemai kiʻekiʻe a i ʻole nā ​​kahua olakino olakino, e hoʻomaʻamaʻa i ka hoʻokumu ʻana i nā moʻolelo olakino maʻi a me ka nānā ikaika. ʻO ka ʻikepili ʻikepili nui e kōkua hou i nā luna olakino i ka ʻike ʻana i nā ʻano anemia kūloko e hoʻomaopopo i nā hoʻolālā pale i manaʻo ʻia [5].

Nā palena

1. Nalo ka ʻike morphological: ʻAʻole hiki ke hāʻawi i nā ʻāpana koʻikoʻi e like me ka mean cell volume (MCV) a me ka laulā puʻupuʻu ʻulaʻula (RDW), e pili ana i ka ʻike ʻana i nā ʻano anemia;
2. Nā mea hoʻopilikia: ʻO ka Hyperbilirubinemia (> 20mg/dL) a i ʻole nā ​​laʻana koko chylous hiki ke alakaʻi i nā hopena ʻino.

ʻO ka holomua hou i ka nānā ʻana i ka hemoglobin portable

ʻenehana hou no ka ʻike pololei

ʻO ka Hemoglobin kahi mole protein i loaʻa i loko o nā keʻena koko ʻulaʻula e lawe ana i ka oxygen mai nā māmā a i nā wahi ʻē aʻe o ke kino. He mea nui ia i ke ola kanaka. Hiki ke hōʻike ʻia nā haʻahaʻa hemoglobin haʻahaʻa he mau maʻi ko ke kanaka, ʻo ia hoʻi ka anemia aplastic, ka maʻi kanesa, ka maʻi maʻi maʻi maʻi, a me ka cirrhosis, no laila pono ka nānā ʻana i ka hemoglobin manawa maoli. Ke hoʻohana nei ka mea hoʻopuka hemoglobin portable ʻo Konsung H7 i ka microfluidic, spectrophotometry, a me ka ʻenehana uku hoʻopuʻi e hōʻoia i ka pololei maʻamau maʻamau (CV ≤ 1.5%) [6-8]. ʻO 7μL wale nō o ke koko manamana lima pono e hōʻiliʻili ʻia, a e hōʻike ʻia nā hopena hōʻike ma ka pale kala TFT i loko o 3 kekona. ʻO ka mālama ʻana i nā hopena hōʻike 2,000 e hāʻawi i ka ʻoluʻolu maikaʻi no ka nānā ʻana i nā pae hemoglobin i ke ola o kēlā me kēia lā.

Me ka hoʻohana ʻana i nā ʻano hemoglobin hilinaʻi a me nā ʻenehana sampling ʻoi aku ka hana, hiki ke ʻike koke ʻia ka Hb a me ka HCT e ʻike a nānā i nā maʻi e like me ka anemia, polycythemia, sickle cell disease, etc. [9-11]. Hoʻohana nui ʻia ia i nā keʻena koko a hiki ke hoʻohana ʻia i ka lāʻau lapaʻau, ka hoʻāʻo ʻana i ka moena, nā hale hana lapaʻau, nā haukapila, etc.

Ka nānā 'ana i nā hi'ohi'ona ho'ohana lapa'au

1. Nānā nui: Ma waena o 5,000 mau hoʻokolohua kino i mālama ʻia ma nā keʻena lapaʻau mua, ua ʻike ka mīkini i ka helu maikaʻi o 12.3% (616 mau hihia) o ka anemia, i kuʻikahi me 91.8% o nā hopena hoʻomaʻamaʻa koko ma hope;
2. Ka nānā ʻana i ka ikaika: ʻO ka hahai ʻana i ka lāʻau hoʻohui hao i nā maʻi me ka anemia deficiency hao i hōʻike ʻia ke ʻano o nā loli o ka HB i ʻike ʻia ua kūlike me ka hoʻomaikaʻi ʻana o nā hōʻailona maʻi (r = 0.79, P
3. He kūpono no nā heluna kanaka: No nā keiki maʻi (3-12 mau makahiki), ʻaʻole i ʻike ʻia ka manaʻo pili makahiki i ka hewa hōʻike (P = 0.45), akā pono e nānā ʻia i ka mana o ka hui ʻana o nā keiki i ka manawa o ka hōʻiliʻili koko.

ʻO ka ʻike a me ka kikoʻī

E koho i 800 mau hōʻailona koko maʻi (me nā hōʻailona kāne 220, nā hōʻailona wahine 300, a me nā hōʻailona keiki 280) [12]. Hana ʻia nā hoʻāʻo ʻana i kēia manawa ma ka BC-5140 mea hoʻokaʻawale koko koko i hana ʻia e Mindray Bio-Medical Electronics Co., LTD. (ma hope aku i kapa ʻia ʻo "BC-5140") a laila ma ka Konsung H7-3 hemoglobin analyzer (ma hope i kapa ʻia ʻo "H7-3"), a ua helu ʻia nā hopena o nā hoʻokolohua ʻelua a ua helu ʻia ka sensitivity a me ka kikoʻī o ka H7-3 hemoglobin analyzer [13]. Hōʻike ka papa 1 i nā hopena o ka hoʻāʻo i hana ʻia ma nā laʻana kāne. Ke hoʻohana nei i kēia mau ʻikepili, ua helu ʻia ka ʻike a me ka kikoʻī, ʻo ia ka 96,70% a me 94,74%.

Papa 1. ʻIke hōʻike kāne kāne

Manaʻo = 176 / (176 + 6) × 100% = 96.70%

ʻIkepili = 36 / (36 + 2) × 100% = 94.74%

Papa 2 hōʻike i nā hopena o ka hoʻokolohua i hana ʻia ma nā laʻana wahine. Me ka hoʻohana ʻana i kēia mau ʻikepili, ua helu ʻia ka naʻau a me ka kikoʻī, ʻo ia ka 96.80% a me 92.00%.

Papa 2. ʻIke hōʻike wahine

ʻIke = 242 / (242 + 8) × 100% = 96.80%

ʻIkepili = 46 / (46 + 4) × 100% = 92.00%

Papa 3 hōʻike i nā hopena o ka hoʻokolohua i hana ʻia ma nā laʻana i lawe ʻia mai nā keiki. Ke hoʻohana nei i kēia mau ʻikepili, ua helu ʻia ka ʻike a me ka kikoʻī, ʻo ia ka 98,33% a me 85,00%.

Papa 3. ʻIke keiki hoʻāʻo

Manaʻo = 236 / (236+4) × 100% = 98.33%

ʻIkepili = 34 / (34 + 6) × 100% = 85.00%

Papa 4 hōʻike i nā hopena o ka ʻikepili hōʻike holoʻokoʻa. ʻO ka sensitivity a me ka kikoʻī o Konsung H7-3 hemoglobin analyzer he 97.32%, a ʻo 90.63% ka kikoʻī.

Papa 4. Huina ikepili hoao

Manaʻo = 654 / (654+18) × 100% = 97.32%

ʻIkepili = 116 / (116+12) × 100% = 90.63%

Nā hāʻina hoʻomalu maikaʻi

Hāʻawi ʻo Konsung i kahi papahana hoʻomalu maikaʻi piha i hoʻolālā ʻia e nānā a hōʻoia i ka pololei o nā hopena hōʻike i hana ʻia e ka H7 hemoglobin analyzer. Aia kēia papahana:

1. Haʻina hoʻomalu maikaʻi Hemoglobin: HBC-3A (Papa L, M, H)
2. Hemoglobin analyzer quality control chip: HBQC-3C (Chip-high, Chip-mid, Chip-low).

Hoʻohālikelike me nā ʻano ʻike ʻē aʻe

ʻano microscopic

ʻO ke ʻano microscopic e hiki ai ke ʻike i ka morphology ʻulaʻula ʻulaʻula like ʻole, e like me nā cell target. Eia nō naʻe, ʻoi aku ka manawa, ʻoi aku ka nui ma mua o 15 mau minuke no kēlā me kēia laʻana, a hilinaʻi nui kona pololei i ka ʻike a me ka ʻike o ka mea hoʻohana.

Mea hoʻoponopono ʻakomi piha

Hāʻawi nā mea hoʻoponopono hematology piha piha i ka nānā ʻana i nā ʻāpana koko piha me ka pololei kiʻekiʻe. Eia nō naʻe, ʻo kā lākou kumukūʻai kiʻekiʻe, mai 20 a 50 mau manawa ʻoi aku ma mua o nā mea kani Konsung, hiki ke lilo i kumu palena no ka hoʻohana ākea.

Mea paʻi kiʻi kiʻi kiʻi kiʻi kalaimetric

Hōʻike kēia mau mea lawe lima i ka hana e like me ka Konsung H7 hemoglobin analyzer. Eia nō naʻe, ʻo 2025, nele lākou i ka hōʻoia mai ka National Medical Products Administration (NMPA), hiki ke kaupalena i kā lākou

ka hoʻopaʻa kino a me ka ʻae hoʻoponopono.

Nā manaʻo hoʻolālā a me nā manaʻo e hiki mai ana

Hoʻonui ʻenehana

Hoʻohui ʻia i ka module AI kiʻi ʻike no ka semi-quantitative analysis o ka ʻulaʻula ʻulaʻula morphology ma o ka hoʻopili ʻana i kahi microscope waho [14]. I kēia manawa, ua hōʻike ʻo AI i ka mana nui ma ke kahua o ka nānā ʻana i nā kiʻi olakino. ʻO ka hoʻokomo ʻana iā ia i loko o nā mea anana hemoglobin hiki ke ʻike maʻalahi i ka nui a me ke ʻano o nā keʻena koko ʻulaʻula, e kōkua ana i nā kauka i ka ʻike koke ʻana i nā ʻano maʻi e like me ka anemia deficiency hao a me ka anemia megaloblastic. Ke hoʻohālikelike ʻia me ka hoʻokolohua microscopic kuʻuna, hiki i AI ke hōʻemi nui i nā hewa kumuhana, hoʻomaikaʻi i ka pono diagnostic a me ka pololei, a kūpono loa i nā hiʻohiʻona kahi i lawa ʻole ai ka ʻike olakino mua.

Nā ho'āʻo helu-nui

ʻO nā hoʻokolohua e like me ka serum ferritin a me ka transferrin saturation e hāʻawi i nā ʻike koʻikoʻi i ka mālama ʻana i ka hao a me ke kūlana halihali, e hiki ai ke hoʻokaʻawale pololei ma waena o nā ʻano anemia. ʻAʻole lawa ka hilinaʻi wale ʻana i kahi hoʻāʻo hemoglobin, no ka mea ʻaʻole ia e ʻike i nā kumu e like me ka hemahema o ka hao, nā maʻi maʻi, a i ʻole nā ​​​​maʻi hematologic [15]. Ma ka hoʻonui ʻana i nā hōʻailona hōʻike, hiki ke hoʻokumu ʻia ke kākoʻo ʻikepili multidimensional no ka maʻi anemia, e kōkua ana i nā kauka e ʻike koke i ke kumu a hoʻomohala i nā hoʻolālā lapaʻau pilikino. ʻAʻole kēia e hoʻomaikaʻi wale i ke kiʻekiʻe o ka mālama mua, akā e hōʻemi hoʻi i ka helu o nā mea kuhikuhi maʻi a hoʻonui i ka hoʻokaʻawale ʻana i nā kumuwaiwai olakino.

Ka hopena

Hōʻike ka mea nānā hemoglobin Konsung i nā pono kūpono a me ka hoʻokele waiwai i ka nānā mua ʻana o ka anemia a hiki ke lilo i mea pono no ka mālama mua. Aia ka hapa nui o nā lako hoʻāʻo a me nā ʻenehana loea i nā keʻena olakino mua. ʻAʻole paʻakikī wale nā ​​mea hoʻāʻo anemia kuʻuna i ka hana, akā loaʻa nō hoʻi nā koi kiʻekiʻe no ke kaiapuni a me nā limahana, e paʻakikī ke hoʻokō wikiwiki i ka hana screening. Ke hoʻohana nei ka Konsung hemoglobin analyzer i kahi ʻano hōʻiliʻili koko fingertip, ʻaʻole koi i ka laʻana pretreatment paʻakikī, a hiki ke hana koke ʻia e nā limahana lapaʻau ma hope o ka hoʻomaʻamaʻa maʻalahi, hoʻopōkole loa i ke kaʻina hoʻāʻo a hoʻomaikaʻi nui i ka pono o ka screening. Ma ke kālā, ʻoi aku ka haʻahaʻa o ke kumukūʻai o nā mea hana a me nā mea hoʻohana ma mua o nā mea hoʻāʻo kuʻuna, hiki ke hōʻemi pono i ke kaumaha kālā ma nā keʻena olakino mua. Eia kekahi, paʻa a paʻa ka hāmeʻa, a hiki ke hoʻololi ʻia i nā lawelawe outpatient i kēlā me kēia lā, ka nānā ʻana i ke kelepona ma nā wahi mamao, a me ka nānā ʻana i ke olakino kaiāulu, e hāʻawi ana i kahi hopena kūpono no ka nānā mua ʻana i ka anemia ma ka pae ʻāina a kōkua i ka hoʻomaikaʻi ʻana i ke kiʻekiʻe o ka pale ʻana a me ka mālama ʻana i ka anemia ma ka pae ʻāina.

ʻŌlelo hōʻike

ʻAʻole kūʻē ka manaʻo o ka mea kākau.

Nā kuhikuhi

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